nad+ anti aging molecule



  • Synonyms: Nicotinamide adenine dinucleotide, diphosphopyridine nucleotide
  • Number of publications: more than 20
  • Molecule availability: self-service
  • Method of administration: for oral use
  • Posology: 100mg/day (minimum)

!Please read the disclamer below!

Evidence of efficiency

Cancer : Studies have shown  that the depletion of NAD+ cells enhances cell degenerescence (in other words, the occurrence of cancers)[1][2]. Thus, replenishing cells with NAD+ is a way of preventing a cancer from occurring.


Cellular rejuvenation: The amount of NAD+ tends to decrease with aging, which can trigger  various mecanisms dysfunction related to this molecule (cell breathing, the  activation of the SIRT1 gene…).

So, the degradation of these mecanisms is related to aging, the addition of NAD+ would allow to keep these mecanisms operational even though these ones already began to deteriorate themselves. Studies were carried out on dying mice, and NAD+ was injected into their body. A rejuvenation of muscles and arteries was observed. This rejuvenation  is essentially due to the impact of NAD+ on mitochondria, which are the organelles responsible for cell breathing, and are the key factors of aging according to most of the specialists. 

neurodegenerative diseases: NAD+ is a necessary molecule for the activation of various molecules like PARP or sirtuins.  Studies have shown that sirtuins play a protective role  in many mecanisms linked to aging, especially for neurodegerative diseases. The NAD+ allows to maintain sirtuins production.

Risk/efficiency: remains to be seen

Supposed effect:  It can  fight cells depletion in NAD+, it allows to activate NAD_dependent molecules (Sirtuins, PARP),  prevents cancer, neurodegeneratives diseases, and rejuvenates tissues.

 Additional molecule:  None

Summary : The nicotinamide adenine dinucleotide (NAD) is a coenzyme that is present in every cell of our organism and is involved in various redox reactions (reduction-oxidation reaction), especially the ATP synthase (necessary source of energy for every reaction of the human body), cellular breathing… Cells can’t live without  NAD+. The NAD+ pool diminution during the aging process can trigger cell death.

Disclaimer: Many studies have been carried out on  NAD+ over the past few years, because of a large amount of mecanisms in which this molecule is involved. All these studies show its key role in our organism, and the experiences on mice have been successful. However, these studies are still recent,  on the long term the efficiency of NAD+ has not been proved yet on humans, and the addition of this molecule only is maybe not sufficient enough to fight against aging mecanisms.


[1] “Scientists Find Promising New Approach to Preventing Progression of Breast Cancer,” accessed November 17, 2016,

[2] “Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion,” n.d.


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