Measuring aging: what is your physiological age?

measuring aging

Physiological age, a measure of aging

Physiological age and chronological age are two different things. Chronological age is determined from the date of birth, and despite what we might think, it does not reflect our “real” age. Our physiological age, also called biological or functional age, is the one that shows the real biological state of a person.

The physiological age of a person can be higher or lower than their chronological age, since aging is not only limited to time, but is in fact a complex process with multiple causes. The evolution of aging can be modulated by internal as well as external factors: genetics, diet, environment, mental health… Knowing your physiological age allows you to better understand the life patterns that have an impact on aging, which in turn allows us to act accordingly to limit its effects.

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Measuring aging: towards a new field of metrology

Metrology is the science of measurements. The metrology of aging concerns any technique that allows to determine the degree and speed of aging of an individual. It can mean identifying and quantifying biological and genetic markers, checking physical capabilities, or observing the physical signs linked to aging.

Although the metrology of aging has not yet reached its peak, many techniques already allow us to determine the physiological age of an individual.

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What are the different methods for measuring aging?

Sometimes, these methods are hardly innovative and are based on well-known scientific facts that are well recognized within the scientific community. They go from the simplest study of a person’s body to the detailed analysis of many physical capabilities and biological traits (Cartographie Physiologique®, Daniel Belsky’s 18 markers…) Many others are real scientific revolutions and call upon technologies that allow the precise identification and measurement of biomarkers that are specific to aging (telomere length, XRGenomics®, DNA methylation levels…) Each has its pros and cons, this review compares the existing methods of aging metrology.

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Part 1: Measuring aging: Cartographie PhysiologiqueⓇ (soon)

mesure du vieillissement physiologiqueThis method to measure aging and physiological age measures the many physical and biological characteristics that were definitely linked to the aging process (cholesterol levels, unipedal stance test, central obesity…)

Part 2: Telomeres, at witnesses of the physiological age, as a tool to measure aging (soon)

mesure du vieillissement télomèresTelomeres can be found at the end of our chromosomes, and get shorter with age. There are many techniques to measure their length (TRFs, Q-Fish, qPCR, STELA…) based on the Southern Blot principle, PCR and in situ hybridization.

Part 3: DNA methylation, a promising lead towards the measure of aging? (soon)

mesure du vieillissement methylation ADNDNA methylation levels grow with the number of divisions a cell undergoes. The number of cell divisions grows with time. Therefore, measuring the methylation of DNA helps to quantify aging. Treating DNA with bisulfites allows to convert non-methylated cytosines into uraciles, so the methylated cytosines can easily be identified. We deduce a physiological age from their numbers.

Part 4: Measuring aging: the eighteen markers of Duke University

mesure du vieillissement Duke University

This method follows the decline of many organic systems (cardiovascular, lungs, kidneys, liver, teeth, and immune system) by quantifying 18 markers for chronic diseases linked to aging. This technique was developed by a research team from Duke University, under the supervision of Dr. Daniel Belsky.

Part 5: Physiognomy and subjective perception of age, what role should they have when measuring aging? (soon)

mesure du vieillissement subjectiveThe physical state is often a reflection of the organic state. With age come physical changes (the loss of bone density changes facial features, lips seem thinner as the teeth become damaged, the nose and ears get longer…) These observations can help determine a biological age.

Part 6: XRGenomics®, a transcriptomic approach to measure aging (soon)

mesure du vieillissement XRGenomics

This technology uses the machine learning method to identify 150 “aging genes” in healthy subjects, and profile the transcriptome of aging. The methylation levels of DNA grow with the number of divisions a cell undergoes.

Farah Bahou

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Author

Auteure

Farah studied biochemistry, therapeutics and molecular and biopharmaceutical innovation at Aix-Marseille university and Paris 7 Diderot university.

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Farah a étudié la biochimie, la thérapeutique et les innovations moléculaires et biopharmaceutiques à l’université d’Aix-Marseille et à l’université Paris 7 Diderot.

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Julie Cavallasca

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Translation

Traduction

Specialized scientific and technical translator for Elvesys and Long Long Life. She graduated with an EMT M.A. in Language Industry and Specialized Translation from Paris 7 University.

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Traductrice scientifique et technique spécialisée pour Elvesys et Long Long Life. Elle détient un master 2 « Industrie de la langue et traduction spécialisée » de l’Université Paris 7 Diderot.

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