Indolepropionamide pill - long long life anti aging transhumanism longevity supplement

Fact sheet

Indolepropionamide : a new hope

Introducing new molecules of interest also means keeping you informed of promising advances in anti-aging research. With indolepropionamide, despite the few studies there are at the moment, we are dealing with THE anti-aging molecule, since it increases up to 300% the lifespan of the models used.

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Long Long Life does not sell any of these products. We believe this to be the price of freedom.

Since we have no financial interest in this, we can tell you the whole truth on the treatments being developped to fight against aging, and give you the best information possible.

A single study, multiple effects

There is only one published study on indolepropionamide and its effect on aging [1]. The team used rotifers, a micro-organism model, for which they observed an increase in lifespan never equaled by other molecules. This longevity was accompanied by better cell repair and increased resistance to injury.

It would seem that this effect is due to a drastic improvement in mitochondrial function accompanied by a significant reduction in the formation of free radicals. The amazing antioxidant properties of indolepropionamide are linked to its structure, very close to that of melatonin, and to its ability to interact with the oxidative phosphorylation chain of mitochondria. It would indeed seem that indolepropionamide is capable of stabilizing mitochondrial energy metabolism by binding to the complex I of the respiratory chain, thus causing a decrease in oxidant production. One of its close cousins, 3-indolepropionic acid, is currently undergoing clinical trials to fight Alzheimer’s disease. It has indeed the same type of properties, because of their homologies of structure, both close to melatonin.

Although new studies are needed, particularly in mammals, indolepropionamide is an extremely promising molecule and its derivatives already seem to offer good prospects, particularly in the fight against neurodegenerative diseases. Moreover, indolepropionamide is an amphiphilic molecule, thus passing as well the cellular membranes as the aqueous structures, and its bioavailability is excellent.

  • Number publications : 1
  • Availability : not available for sale
  • Route : intravenous
  • Dosage : to be defined

No toxicity has been reported to date but further studies are needed.

[1] Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan. Blagosklonny MV, ed. PLoS ONE. 2010;5(4):e10206

DISCLAIMER

The information on the present website does not constitute either directly or indirectly any medical advice. The provided information is intended to inform and is in no way a substitute for the direct relationship between a patient and a health professional. Under no circumstances the information on the website are likely to make up for consulting, visiting and diagnosis by a licensed healthcare professional. Said information should not be interpreted as ensuring the promotion any molecule or medical product.

Long Long Life will not be held liable for any action or decision-making in relation to the information on this website.

Long Long Life does not guarantee by any means any result following the implementation of the published information on the website.

Self-medication can be dangerous for your health, please seek medical advice before starting any treatment.

Dr. Marion Tible

Marion Tible Long Long Life

Author/Reviewer

Auteure/Relectrice

Marion Tible has a PhD in cellular biology and physiopathology. Formerly a researcher in thematics varying from cardiology to neurodegenerative diseases, she is now part of Long Long Life team and is involved in scientific writing and anti-aging research.

More about the Long Long Life team

Marion Tible est docteur en biologie cellulaire et physiopathologie. Ancienne chercheuse dans des thématiques oscillant de la cardiologie aux maladies neurodégénératives, elle est aujourd’hui impliquée au sein de Long Long Life pour la rédaction scientifique et la recherche contre le vieillissement.

En savoir plus sur l’équipe de Long Long Life

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