Indolepropionamide : a new hope
Introducing new molecules of interest also means keeping you informed of promising advances in anti-aging research. With indolepropionamide, despite the few studies there are at the moment, we are dealing with THE anti-aging molecule, since it increases up to 300% the lifespan of the models used.
A single study, multiple effects
There is only one published study on indolepropionamide and its effect on aging . The team used rotifers, a micro-organism model, for which they observed an increase in lifespan never equaled by other molecules. This longevity was accompanied by better cell repair and increased resistance to injury.
It would seem that this effect is due to a drastic improvement in mitochondrial function accompanied by a significant reduction in the formation of free radicals. The amazing antioxidant properties of indolepropionamide are linked to its structure, very close to that of melatonin, and to its ability to interact with the oxidative phosphorylation chain of mitochondria. It would indeed seem that indolepropionamide is capable of stabilizing mitochondrial energy metabolism by binding to the complex I of the respiratory chain, thus causing a decrease in oxidant production. One of its close cousins, 3-indolepropionic acid, is currently undergoing clinical trials to fight Alzheimer’s disease. It has indeed the same type of properties, because of their homologies of structure, both close to melatonin.
Although new studies are needed, particularly in mammals, indolepropionamide is an extremely promising molecule and its derivatives already seem to offer good prospects, particularly in the fight against neurodegenerative diseases. Moreover, indolepropionamide is an amphiphilic molecule, thus passing as well the cellular membranes as the aqueous structures, and its bioavailability is excellent.
- Number publications : 1
- Availability : not available for sale
- Route : intravenous
- Dosage : to be defined
No toxicity has been reported to date but further studies are needed.
 Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan. Blagosklonny MV, ed. PLoS ONE. 2010;5(4):e10206
Dr. Marion Tible
Marion Tible has a PhD in cellular biology and physiopathology. Formerly a researcher in thematics varying from cardiology to neurodegenerative diseases, she is now part of Long Long Life team and is involved in scientific writing and anti-aging research.
More about the Long Long Life team
Marion Tible est docteur en biologie cellulaire et physiopathologie. Ancienne chercheuse dans des thématiques oscillant de la cardiologie aux maladies neurodégénératives, elle est aujourd’hui impliquée au sein de Long Long Life pour la rédaction scientifique et la recherche contre le vieillissement.
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